Symptoms of polyneuropathy /
Polyneuropathy manifests itself as hypersensitivity to stimuli, pain, burning and/or tingling in the hands and feet, loss of sensitivity (numbness), in some cases with associated problems relating to coordination of movement and balance. Those affected are barely able to distinguish between hot and cold, or this ability may even be lost completely. The primary effects include paraesthesia (abnormal sensation in skin) and pains.
A special form of the disease, hand-foot syndrome, occurs when there is an associated inflammatory skin reaction in the hands and feet. Complaints are varied: painful areas of red skin, burning sensations (sometimes with skin abrasions), excess sensitivity to pain and at later stages, even numbness.
Where acute symptoms present during chemotherapy, the treatment intervals must often be extended, the dose reduced, and, in the most severe cases, the treatment discontinued entirely.
Grade 1: Tingling, painless swelling or erythema of the hands and/or feet, or complaints that do not impact on the patient’s everyday activities.
Grade 2: Painful erythema and swelling of the hands and/or feet, and/or complaints that impact on the patient’s everyday activities.
Grade 3: A moist peeling of the skin, ulceration, blistering and severe pain in the hands and/or feet, and/or severe symptoms which make it impossible for the patient to work or carry out the activities of daily life.